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Treatment

Patients with hypertension should work with their doctors to set blood pressure goals based on individual risk factors. Lifestyle and medication programs need to be planned on an individual basis.

Healthy lifestyle changes are imperative for anyone, and are critical for people with even normal blood pressure (120/80 mm Hg) and above. In appropriate patients, aggressive drug treatment of long-term high blood pressure can significantly reduce the incidence of mental decline and death from heart disease and other serious physical effects of hypertension. In people with diabetes, controlling both blood pressure and blood glucose levels prevents serious complications of that disease. Anti-hypertensive drugs may even prevent mental decline, including in people genetically susceptible to Alzheimer's disease. Nevertheless, only slightly over half of patients with hypertension are treated at all, and only a quarter have adequately controlled pressure.

It is not clear when drugs should be started, particularly for people with prehypertension or mild high blood pressure. To help make treatment choices, the U.S. National Heart, Lung, and Blood Institute has created categories (denoted as groups A, B, and C) according to a patient's risk factors for heart disease. Applying these categories to the severity of hypertension helps determine whether lifestyle changes alone or medications are needed.

Treatment Recommendations by Stage and Risk Groups

Risk Groups Blood Pressure Stages (Systolic/Diastolic)
  Prehypertension
(120 - 139/80 - 89)
Mild (Stage 1) Blood Pressure
(140 - 159/90 - 99)
Moderate-to-Severe (Stage 2) Blood Pressure

(Systolic pressure over 160 or diastolic pressure over 100)
Risk Group A
Have no risk factors for heart disease.
Lifestyle changes only. (Exercise and dietary program with regular monitoring.) Year trial of lifestyle changes only. If blood pressure is not lower at 1 year, add drug treatments. Lifestyle changes and medications.
Risk Group B
Have at least one risk factor for heart disease* (excluding diabetes) but have no target organ damage (such as in the kidneys, eyes, or heart, or existing heart disease).
Lifestyle changes only. 6-month trial of lifestyle changes only. If blood pressure is not lower at 6 months, add drug treatments.

Medications considered for patients with multiple risk factors.
Lifestyle changes and medications.
Risk Group C
Have diabetes with or without target organ damage and existing heart disease (with or without risk factors for heart disease).
Lifestyle changes and medications. Lifestyle changes and medications. Lifestyle changes and medications.
* Risk factors for heart disease include the following: family history of heart disease, smoking, unhealthy cholesterol and lipid levels, diabetes, being over 60 years old.
Review Date: 12/21/2006
Reviewed By: Harvey Simon, MD, Associate Professor of Medicine, Harvard Medical School; Physician, Massachusetts General Hospital.

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